منابع مشابه
SnapShot: Cancer Vaccines
This SnapShot illustrates the main concepts and underlying biology of therapeutic vaccination in cancer. Dendritic cells (DCs) are an essential component of vaccination through their capacity to capture, process, and present antigens to T cells. We have come a long way in our understanding of what is needed to elicit therapeutic immunity when cancer escapes the natural barrier of protective imm...
متن کاملSnapShot: cancer metabolism pathways.
See online version for legend and references. 466 Cell Met. 17-3, March 5, 2013 ©2013 Elsevier Inc. DOI http://dx.doi.org/10.1016/j.cmet.2013.02.016 enzyme Oncogenic alteration functional outcome PFKFB3 The PFK2 isoform PFKFB3 is highly expressed in several human cancers, including colon, prostate, breast, ovary, and thyroid. Most PFK2 isoforms both generate and degrade F-2,6-bisP, which activa...
متن کاملSnapShot: Lung Cancer Models
K-ras activation K-rasLSL-G12D or K-rasLSL-G12V Cre-dependent expression of oncogenic K-rasG12D or K-rasG12V from endogenous locus. Viral cre delivery via adenoviral or lentiviral inoculation (intranasal or intratracheal). Adenocarcinoma spectrum histology (i.e., in situ and invasive neoplasia) in lung; metastasis not reported. K-ras somatic mutations identified in ~20%30% of lung adenocarcinom...
متن کاملSnapShot: MicroRNAs in Cancer
let-7 family (various) Downregulated in lung, breast, gastric, ovary, prostate and colon cancers, CLL, leiomyomas; miR-98 downregulated in head and neck cancer. Point mutation in let-7e transcript affects miRNA maturation. Repress cell proliferation and growth. let-7f promotes angiogenesis. Targets: CCND1, CDC25a, CDC34, CDK6, CRDBP, DICER, HMGA2, HOXA9, IMP-1, ITGB3, MYC, RAS, TLR4. SNP in K-R...
متن کاملThoracoscopic Splanchnicectomy for Pain Control in Irresectable Pancreatic Cancer
Introduction : Severepain is a major problem in patients with unresectable pancreatic cancer. The goal of this study is to evaluate the effects of Thoracoscopic Splanchnicectomy (TS) on pain control in these patients suffering from unresectable pancreatic cancer. Methods:Between years 2000 to 2011, 20 patients suffering from unresectable pancreatic cancer underwent TS due to severe pain. They w...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2013
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2013.03.008